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Interestingly, research has shown that even in animals lacking beta-3 adrenergic receptors, acute AOD-9604 administration still increased energy expenditure and fat oxidation, suggesting additional metabolic pathways may be involved beyond the primary beta-3 receptor mechanism

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Statins have direct neuroprotective effects through inhibition of brain HMG-CoA reductase, reduction of platelet activity in the cerebral vasculature, stabilization of atherosclerotic plaques, and modulation of Rho GPTase activity

There is an increased risk of suicidal ideation and behavior in patients receiving AEDs to treat epilepsy, psychiatric disorders, or other conditions (e.g., migraine, neuropathic pain)